Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: That is an impurity related to bortezomib, a proteasome inhibitor used in the remedy of a number of myeloma. Its synthesis or examine is critical for making certain the purity and security on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor within the synthesis of abiraterone acetate, a drug Employed in the treatment method of prostate cancer by inhibiting androgen output.
Imatinib Intermediate (CAS NO. 152460-ten-one): A vital compound from the synthesis of imatinib, a drug that targets unique varieties of cancer, together with Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats a variety of cancers like breast, lung, and prostate cancer.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They are intermediates within the synthesis of gemcitabine, an anti-cancer drug. Their examine is significant for optimizing the manufacturing system and making certain superior purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is employed to take care of breast cancer, and these intermediates are involved with its manufacturing.
Fulvestrant Intermediates: Fulvestrant can be an estrogen receptor antagonist Utilized in the remedy of breast cancer. Several intermediates help in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug Imatinib intermediate powerful in managing cancers such as ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug used in the remedy of colorectal cancer and smaller mobile lung most cancers.
three-Amino-1-hydroxyadamantane (CAS 702-82-9): This compound is involved in the synthesis of adamantane derivatives, which have a variety of apps, including antiviral properties.
Vildagliptin Intermediates: Used in the production of vildagliptin, an oral drug for kind 2 diabetes that inhibits the enzyme DPP-4 to control blood sugar levels.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is involved with the synthesis of varied gluconic acid derivatives, that happen to be 7-dihydro-4-oxo-1H-pyrrolo[2 Employed in food, pharmaceutical, and industrial programs.
Canagliflozin Intermediate 2: A precursor in the synthesis of canagliflozin, a medication applied to control form 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).